| Title | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. | ||
| Author | Ishizuka, Satoshi; Yamaya, Mutsuo; Suzuki, Tomoko; Takahashi, Hidenori; Ida, Shiroh; Sasaki, Takahiko; Inoue, Daisuke; Sekizawa, Kiyohisa; Nishimura, Hidekazu; Sasaki, Hidetada | ||
| Journal | J Infect Dis | Publication Year/Month | 2003-Dec |
| PMID | 14673774 | PMCID | -N/A- |
| Affiliation | 1.Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan. | ||
To examine the effects of rhinovirus (RV) infection on the adherence of Streptococcus pneumoniae to human tracheal epithelial cells, cells were infected with RV-14, and S. pneumoniae were added to the culture medium. The number of S. pneumoniae adhering to epithelial cells increased after RV infection. Y-24180, a specific inhibitor of the platelet-activating factor receptor (PAF-R); PAF; and the pyrrolidine derivative of dithiocarbamate, an inhibitor of transcription factor nuclear factor-kappaB (NF-kappaB), decreased the number of S. pneumoniae adhering to cells after RV-14 infection. RV-14 infection increased PAF-R expression and the activation of NF-kappaB and promoter-specific transcription factor 1. These findings suggest that RV-14 infection stimulates S. pneumoniae adhesion to airway epithelial cells via increases in PAF-Rs that are partly mediated through activation of transcription factors. Increased adherence of S. pneumoniae may be one of the reasons that pneumonia develops after RV infection.