| Title | Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1. | ||
| Author | Hardin, Bradley A; Lowe, Miriam R; Bhakta, Deepak; Groh, William J | ||
| Journal | Ann Noninvasive Electrocardiol | Publication Year/Month | 2003-Jul |
| PMID | 14510658 | PMCID | PMC6931928 |
| Affiliation | 1.Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. | ||
BACKGROUND: Cardiac myopathy manifesting as arrhythmias is common in the neurological disease, myotonic dystrophy type 1 (DM1). The purpose of the present study was to evaluate heart rate variability (HRV) in patients with DM1. METHODS: In a multicenter study, history, ECG, and genetic testing were performed in DM1 patients. RESULTS: In 289 patients in whom the diagnosis of DM1 was confirmed by a prolonged cytosine-thymine-guanine (CTG) repeat length the most common ambulatory ECG abnormality was frequent ventricular ectopy (16.3%). The 24-hour time domain parameters of SDNN (SD of the NN interval) and SDANN (SD of the mean NN, 5-minute interval) declined as age and CTG repeat length increased (SDNN: -8.5 ms per decade, 95% confidence intervals [CI]-12.9, -4.2, -8.7 ms per 500 CTG repeats, CI -15.7, -1.8, r=0.24, P<0.001; SDANN: -8.1 ms per decade, CI -12.4, -3.8, -8.8 ms per 500 CTG repeats, CI -15.7, -1.9, r=0.23, P<0.001). Short-term frequency domain parameters declined with age only (total power: -658 ms2 per decade, CI: -984, -331, r=0.23, P<0.001; low frequency (LF) power -287 ms2 per decade, CI: -397, -178, r=0.30, P<0.001; high frequency (HF) power: -267 ms2 per decade, CI: -386, -144, r=0.25, P<0.001). The LF/HF ratio increased as the patient aged (0.5 per decade, CI: 0.1, 0.9, r=0.13, P=0.03). CONCLUSIONS: In DM1 patients a decline in HRV is observed as the patient ages and CTG repeat length increases.