| Title | Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis. | ||
| Author | Niehaus, M D; Gwaltney, J M Jr; Hendley, J O; Newman, M J; Heymann, P W; Rakes, G P; Platts-Mills, T A; Guerrant, R L | ||
| Journal | J Clin Microbiol | Publication Year/Month | 2000-Aug |
| PMID | 10921988 | PMCID | PMC87198 |
| Affiliation | 1.Divisions of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. | ||
To distinguish sinusitis from uncomplicated "colds," we examined lactoferrin and eosinophilic cationic protein (ECP) in nasal secretions. Lactoferrin titers were >/=1:400 in 4% of persons with uncomplicated colds and controls but in 79% of persons with sinusitis or purulent sputa. ECP levels were >200 ng/ml in 61% of persons with colds and >3,000 ng/ml in 62% of persons with sinusitis. Nasal lactoferrin helps distinguish sinusitis from colds.