| Title | Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position. | ||
| Author | Hamdouchi, C; Ezquerra, J; Vega, J A; Vaquero, J J; Alvarez-Builla, J; Heinz, B A | ||
| Journal | Bioorg Med Chem Lett | Publication Year/Month | 1999-May |
| PMID | 10360742 | PMCID | -N/A- |
| Affiliation | 1.Centro de Investigacion Lilly S.A., Alcobendas (Madrid)-Spain. hamdouchi_chafiq@lilly.com. | ||
Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1 ,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the anti-rhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed.